一、个人简介
侯路宽，男，博士，讲师，中共党员。2018年6月毕业于中国海洋大学，获得博士学位。2019-2021年，在美国南卡莱罗纳大学从事博士后研究工作。2022年加入金沙检测线路js69金沙检测线路js69。
二、研究领域
1. 基因组信息指导下的微生物活性天然产物的定向发掘；
2. 微生物活性天然产物的合成生物学研究；
三、科研项目
1. 国家自然科学基金青年科学基金项目，30万，2024/01-2026/12，主持。
2. 陕西省自然科学基础研究计划，一般项目（青年），5万，2024/01-2025/12，主持。
3. 金沙检测线路js69博士科研启动基金，20万，2022/06-2025/04，主持。
4．国家自然科学基金委员会, 联合基金项目，257万，2023/01-2026/12，参与。
5. 国家自然科学基金委员会, 联合基金项目，286万，2018/01-2021/12，参与。
四、开设课程
《微生物学》、《微生物学实验》
五、主要科研成果
1. Hou LK, Wang SY, Zhang YH, Yang X, Chen ZH, Gao YX, Li WL*. Targeted discovery of diterpene compounds ostamycins with anti-influenza A viral activity from a deepsea-derived Streptomyces strain. Bioorganic Chemistry , 2025: 108268.
2. Ma GY#, Hou LK#, Guo JH, Sun JC, Nong QN, Wang YF, Hu SW, Zhao WJ, Tan J, Liu XF, Guo Y, Zhang BJ, Wang HL, Wang SY, Li XQ, Cao W*. The structures of two polysaccharides from Fructus Corni and their protective effect on insulin resistance. Carbohydrate Polymers , 2025: 123290.
3. Pulliam C#, Hou LK#, Xue D, Xu MM, Holandez-Lopez K, Li J*. A Bacterial Sulfotransferase Catalyzes an UnusualDi-Sulfation in Natural Products Biosynthesis. ChemBioChem , 2025: 2500024.
4. Hou LK#, Yang X#, Wang SY, Li WL*.New phenazines from Taibai mountain-derived Streptomyces xanthophaeus A54. Natural Product Research , 2025 (Accepted).
5. Wu XT#, Hou LK#, Zhang HL, Ma Y, Wang JF, Cai MW*, Tang XY*. Identification of 3-ketocapnine reductase activity within the human microbiota. Mlife , 2024, 3(2): 307–316.
6. Hou LK#, Tian HY#, Wang L, Ferris ZE, Wang JF, Cai MW, Older EA, RajaMRK, Xue D, Sun WY, Nagarkatti P, Nagarkatti M, ChenHX, Fan DP, Tang XY* and Li J*. Identification and biosynthesis of pro-inflammatory sulfonolipids from an opportunistic pathogen Chryseobacterium gleum . ACS Chemical Biology, 2022, 17(5): 1197–1206.
7. Hou LK#, Li Y#, Wu QH, Li MY, Older EA, Tang XY, Nagarkatti P, Nagarkatti M, Li LJ, Fan DP, Bugni T, Shang Z*, Li J*. Discovery of anti-infective adipostatins through bioactivity-guided isolation and heterologous expression of a type Ⅲ polyketide synthase. Bioorganic Chemistry , 2021, 112: 104925.
8. Hou LK, Liu ZZ, Yu DQ, Li HY*, Ju JH, Li WL*. Targeted discovery of novel polycyclic tetramate macrolactams from deepsea-derived Streptomyces somaliensis SCSIO ZH66. Bioorganic Chemistry , 2020, 101: 103954.
9. Hou LK, Huang HM, Li HY, Wang SY, Ju JH, Li WL*. Overexpression of a type III PKS gene affording novel violapyrones with enhanced anti-influenza A virus activity. Microbial Cell Factories , 2018, 17: 1–11.
10. Hou LK, Wang SY, Huang HM, Li HY, Li WL*. Generation of methylated violapyrones with improved anti-influenza A virus activity by heterologous expression of a type III PKS gene in a marine Streptomyces strain. Bioorganic & Medicinal Chemistry Letters , 2018, 28(17): 2865–2868.
11. Han X#, Hou LK#, Hou J, Zhang YY, Li HY*, Li WL*. Heterologous expression of a VioA variant activates cryptic compounds in marine-derived Brevibacterium sp. Marine Drugs , 2018, 16(6): 191.
12. 侯路宽, 李花月, 李文利*. 隐性次级代谢产物生物合成基因簇的激活及天然产物定向发现. 微生物学报 , 2017, 57(11): 1722–1734.
13. Xue D#, Older EA#, Zhong Z#, Shang Z, Chen NZ, Dittenhauser N, Hou LK, Walla MD, Dong SH, Tang XY, Nagarkatti P, Nagarkatti M, Li YX*, Li J*. Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes. Nature Communications , 2022, 13(1): 1647.
14. Zhang YY, Zhao YN, Wang NN, Wang HR, Yang P, Zhai YJ, Hou LK, Li WL*. Characterization of the Biosynthesis of Pimprinine-Type Indolyloxazoles Unravels an Unusual D-Configurational Substrate Metabolic Streamline. Journal of the American Chemical Society , 2025. https://doi.org/10.1021/jacs.5c01705.
15. 授权专利: 李文利，侯路宽，李花月，黄会明，吡喃酮类化合物及制备方法、用途。2020. 04. 28，中国，ZL201810115669. 3.
六、联系方式
通讯地址：陕西杨凌西农路22号，金沙检测线路js69金沙检测线路js69
邮编：712100
邮箱：houlukuan@nwafu.edu.cn
